CYP2D6 genotyping and the use of tamoxifen in breast cancer.

نویسنده

  • Donald Berry
چکیده

jnci.oxfordjournals.org 5. Guenther PM, Reedy J, Krebs-Smith SM. Development of the Healthy Eating Index–2005. J Am Diet Assoc. 2008;108(11):1896–1901. 6. Kennedy ET, Ohls J, Carlson S, Fleming K. The Healthy Eating Index: design and applications. J Am Diet Assoc. 1995;95(10):1103–1108. 7. Reedy J, Krebs-Smith SM, Bosire C. Evaluating the food environment: application of the Healthy Eating Index–2005. Am J Prev Med. 2010;38(5):465–471. 8. Kirkpatrick SI, Reedy J, Kahle LL, Harris JL, Ohri-Vachaspati P, Krebs-Smith SM. Fast-food menu offerings vary in dietary quality, but are consistently poor [published online ahead of print January 15, 2013]. Pub Health Nutr. doi:10.1017/S1368980012005563. 9. Krebs-Smith SM, Reedy J, Bosire C. Healthfulness of the U.S. food supply: little improvement despite decades of dietary guidance. Am J Prev Med. 2010;38(5):472–477. 10. Guenther PM, WY Juan, Lino M, Hiza HA, Fungwe T, Lucas R. Diet Quality of Low-Income and Higher Income Americans in 2003–04 as measured by the Healthy Eating Index–2005. Washington, DC: Center for Nutrition Policy and Promotion, US Department of Agriculture; 2008. 11. Guenther PM, Reedy J, Krebs-Smith SM, Reeve BB. Evaluation of the Healthy Eating Index–2005. J Am Diet Assoc. 2008;108(11):1854–1864. 12. Reedy J, Mitrou PN, Krebs-Smith, SM, et al. Index-based dietary patterns and risk of colorectal cancer: the NIH–AARP Diet and Health Study. Am J Epidemiol. 2008;168(1):38–48. 13. Reedy J, Wirfält E, Flood A, et al. Comparing 3 dietary pattern methods—cluster analysis, factor analysis, and index analysis—with colorectal cancer risk: the NIH–AARP Diet and Health Study. Am J Epidemiol. 2010;171(4):479–487. 14. Guenther PM, Casavale KO, Reedy J, et al. Update of the Healthy Eating Index: HEI–2010. J Acad Nutr Diet. 2013;113(4):569–580.

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منابع مشابه

Re: CYP2D6 genotyping and the use of tamoxifen in breast cancer.

Donald Berry in his recent editorial (1) regarding the role of CYP2D6 and tamoxifen highlights several controversies that exist in the clinical and biomarker field for women with breast cancer. The International Tamoxifen Pharmacogenomics Consortium (ITPC) was formed with the intent to aggregate, curate, and analyze the data available in published breast cancer studies with the hope of answerin...

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Predictive Biomarkers and Personalized Medicine Evaluation of CYP2D6 and Efficacy of Tamoxifen and Raloxifene in Women Treated for Breast Cancer Chemoprevention: Results from the NSABP P1 and P2 Clinical Trials

Background: Controversy exists regarding the association between CYP2D6 enzyme activity and tamoxifen effectiveness in the adjuvant treatment of invasive breast cancer; however, this association in the primary prevention of breast cancer is unknown. Methods:We conducted a nested case–control study in the context of the NSABP P1 and P2 prevention trials to determine the impact of CYP2D6 genotype...

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Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials.

BACKGROUND Controversy exists regarding the association between CYP2D6 enzyme activity and tamoxifen effectiveness in the adjuvant treatment of invasive breast cancer; however, this association in the primary prevention of breast cancer is unknown. METHODS We conducted a nested case-control study in the context of the NSABP P1 and P2 prevention trials to determine the impact of CYP2D6 genotyp...

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Impaired tamoxifen metabolism reduces survival in familial breast cancer patients.

PURPOSE Tamoxifen has been the mainstay adjuvant hormonal treatment for breast cancer for many years. Conversion of tamoxifen to its active metabolite, endoxifen, is reduced by low activity of the cytochrome P450 enzyme, CYP2D6. We examined the effect of reduced CYP2D6 activity on the response to tamoxifen in patients with familial early-onset breast cancer. EXPERIMENTAL DESIGN We conducted a...

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Functional Polymorphisms in Xenobiotic Metabolizing Enzymes and Their Impact on the Therapy of Breast Cancer

Breast cancer is the top cancer among women, and its incidence is increasing worldwide. Although the mortality tends to decrease due to early detection and treatment, there is great variability in the rates of clinical response and survival, which makes breast cancer one of the most appealing targets for pharmacogenomic studies. The recognition that functional CYP2D6 polymorphisms affect tamoxi...

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Influence of CYP2D6 Polymorphisms on Serum Levels of Tamoxifen Metabolites in Spanish Women with Breast Cancer

BACKGROUND Estrogen receptor-positive breast cancer tumors depend on estrogen signaling for their growth and replication and can be treated by anti-estrogen therapy with tamoxifen. Polymorphisms of the CYP2D6 and CYP2C19 genes are associated with an impaired response to tamoxifen. The study objective was to investigate the impact of genetic polymorphisms in CYP2D6 and CYP2C19 on the pharmacokin...

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عنوان ژورنال:
  • Journal of the National Cancer Institute

دوره 105 17  شماره 

صفحات  -

تاریخ انتشار 2013